A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann · 2026
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Description
Leila Pourtalebi Jahromi and colleagues lay out a chemistry guide for refitting the surface of extracellular vesicles, in a 2026 review. Vesicles are tiny parcels cells shed, and drug makers covet them as natural delivery trucks. The snag is control: a raw vesicle shows sticky, changeable surface proteins that steer where it lands and how fast the body clears it.
Borrowed lab tricks from antibody coupling and bioorthogonal chemistry let makers graft homing tags, cloaks, and sensors onto the shell. The authors widen the menu with chemistries borrowed from protein and cell surface work, still untried on vesicles. Lipid engineering rounds out the toolkit. The closing call is for shared yardsticks, since matching how teams describe these grafts is what will let results add up.
Catalog record
| CREATOR | Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |