A Phase Ib Case Series Using Bortezomib With Chemotherapy in Atypical Teratoid/Rhabdoid Tumors
Wan‐Ling Ho, Ming‐Yun Hsieh, Yu‐Mei Liao, Shyh‐Shin Chiou, Her‐Shyong Shiah, Chang‐Hsu Chiang, Shiann‐Tarng Jou, Hsiu‐Ju Yen, Yi‐Yen Lee, Muh‐Lii Liang, Ting‐Chi Yeh, Yu‐Cheng Chou, Fang‐Liang Huang, Shu‐Huey Chen, Hsin‐Lun Lee, Chia‐Chun Kuo, Yi‐Shan Yang, Shu‐Mei Chen, Min‐Lan Tsai, Hsi Chang, Kev · 2026
Read A Phase Ib Case Series Using Bortezomib With Chemotherapy in Atypical Teratoid/Rhabdoid Tumors by Wan‐Ling Ho, Ming‐Yun Hsieh, Yu‐Mei Liao, Shyh‐Shin Chiou, Her‐Shyong Shiah, Chang‐Hsu Chiang, Shiann‐Tarng Jou, Hsiu‐Ju Yen, Yi‐Yen Lee, Muh‐Lii Liang, Ting‐Chi Yeh, Yu‐Cheng Chou, Fang‐Liang Huang, Shu‐Huey Chen, Hsin‐Lun Lee, Chia‐Chun Kuo, Yi‐Shan Yang, Shu‐Mei Chen, Min‐Lan Tsai, Hsi Chang, Kev (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13578914.txt.
Description
Wan-Ling Ho and co-authors test whether adding a proteasome blocker to chemotherapy is safe in children with a rare, vicious brain tumor, in a 2026 case series. Atypical teratoid/rhabdoid tumors strike the very young and resist most therapy; lab models suggested they are sensitive to proteasome inhibitors like bortezomib. Six patients, aged under one to thirteen, received the drug on four days of each twenty-one-day chemo cycle, for up to six cycles.
Thirty cycles were evaluated. No severe non-blood toxicity was blamed on bortezomib. Four children finished all six cycles; two stopped early as their disease progressed. Of the four whose response could be judged, two shrank, one held steady, one grew. Two children remain alive and disease-free past three years. The authors conclude the combination is feasible, with toxicity no worse than chemotherapy alone.
Catalog record
| CREATOR | Wan‐Ling Ho, Ming‐Yun Hsieh, Yu‐Mei Liao, Shyh‐Shin Chiou, Her‐Shyong Shiah, Chang‐Hsu Chiang, Shiann‐Tarng Jou, Hsiu‐Ju Yen, Yi‐Yen Lee, Muh‐Lii Liang, Ting‐Chi Yeh, Yu‐Cheng Chou, Fang‐Liang Huang, Shu‐Huey Chen, Hsin‐Lun Lee, Chia‐Chun Kuo, Yi‐Shan Yang, Shu‐Mei Chen, Min‐Lan Tsai, Hsi Chang, Kev |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |