Reduced circulating polyamines in polyendocrine metabolic ovarian syndrome patients and the impact of putrescine on ovarian function and fertility in a murine PMOS model†
Subrata Das, Joseph R D Fernandes, P T Nikhil, S Narayana, Gayatri Shinde, Srabani Mukherjee, Chandrika Anand, N Suchetha Kumari, Sridev Mohapatra, Arnab Banerjee · 2026
Read Reduced circulating polyamines in polyendocrine metabolic ovarian syndrome patients and the impact of putrescine on ovarian function and fertility in a murine PMOS model† by Subrata Das, Joseph R D Fernandes, P T Nikhil, S Narayana, Gayatri Shinde, Srabani Mukherjee, Chandrika Anand, N Suchetha Kumari, Sridev Mohapatra, Arnab Banerjee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13578486.txt.
Description
Subrata Das and colleagues link low blood levels of polyamines, small molecules that steer the brain's fertility hormone, to a hormonal ovary syndrome in women. Blood tests showed putrescine, spermidine and spermine all lower in patients than in healthy women. In young mice given a syndrome-like state, the team then dosed polyamines for five days.
One dose of putrescine eased the mouse syndrome: the fertility hormone, sugar, testosterone, body weight and ovary inflammation all fell. Treated mice also bred and carried pregnancies better, with healthier womb markers. The authors propose polyamine levels as part of the syndrome's machinery and a target for care.
Catalog record
| CREATOR | Subrata Das, Joseph R D Fernandes, P T Nikhil, S Narayana, Gayatri Shinde, Srabani Mukherjee, Chandrika Anand, N Suchetha Kumari, Sridev Mohapatra, Arnab Banerjee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |