ISWI/CHRAC orchestrates sequential chromatin-remodeling activities by mobilizing DNA polymerase ε for homologous recombination
Jianghao Qian, Kozo Tanaka, Akira Yasui, Ayako Ui · 2026
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Description
Jianghao Qian and co-authors trace how cells rebuild broken DNA by copying the sound copy, a repair path that needs room to work. DNA sits packed in a spool-like wrap that must be loosened and reset for repair crews to reach a break. Their 2026 study centers on one part of a wrap-shifting complex and its dual role in a DNA copying crew.
When a break hits, the complex lands at the site at once and helps lay fresh wrap. Key repair proteins are drawn in, and later steps of the copy-based repair gain from more wrap shifts. The copying crew itself is also brought in through the shared part. Cells with this path intact resist a class of cancer drugs. The work maps a linked dance of wrap work and repair that keeps the genome whole.
Catalog record
| CREATOR | Jianghao Qian, Kozo Tanaka, Akira Yasui, Ayako Ui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |