Finerenone in Cardiorenal Disease: A Narrative Review of Molecular Mechanisms, Clinical Evidence, and Emerging Therapeutic Roles
Giulio Geraci, Nicola Sinatra, Valentina Paternò, Vincenzo Calabrese, Giuliano Cassataro, Giuseppe Cuttone, Calogero Geraci, Roberta Esposito, Costantino Mancusi, Giacomo Pucci, Luca Zanoli, Giuseppe Mulè, Riccardo Polosa, Pietro Ferrara, Caterina Carollo · 2026
Read Finerenone in Cardiorenal Disease: A Narrative Review of Molecular Mechanisms, Clinical Evidence, and Emerging Therapeutic Roles by Giulio Geraci, Nicola Sinatra, Valentina Paternò, Vincenzo Calabrese, Giuliano Cassataro, Giuseppe Cuttone, Calogero Geraci, Roberta Esposito, Costantino Mancusi, Giacomo Pucci, Luca Zanoli, Giuseppe Mulè, Riccardo Polosa, Pietro Ferrara, Caterina Carollo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13578082.txt.
Description
Giulio Geraci and co-authors review a drug called finerenone in a 2026 survey of heart and kidney disease. The two organs fail together often, driven by hormone signals, swelling, and scar tissue. The drug blocks a hormone receptor that, when overactive, harms both organs even apart from blood pressure.
Large trials covered in the review show the drug slowed kidney decline and cut heart events in people with type 2 diabetes and kidney disease. A later trial extended the gains to people with a common form of heart failure, with or without diabetes. High potassium was the main risk, yet it stayed rare when patients were checked on a set schedule. The review also weighs early hints of help for the eyes and liver.
Catalog record
| CREATOR | Giulio Geraci, Nicola Sinatra, Valentina Paternò, Vincenzo Calabrese, Giuliano Cassataro, Giuseppe Cuttone, Calogero Geraci, Roberta Esposito, Costantino Mancusi, Giacomo Pucci, Luca Zanoli, Giuseppe Mulè, Riccardo Polosa, Pietro Ferrara, Caterina Carollo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |