A study on extracellular and cellular composition to advance towards the rational design of contractile human myocardium
Olalla Iglesias-García, Asier Ullate-Agote, Jiabin Qin, Aida Oliván-Viguera, Laura García-Mendívil, Gerardo Cedillo-Servin, Johannes Braig, Jose Valdés-Fernández, Inge Dokter, Ilazki Anaut-Lusar, Eduardo Larequi, Patxi San Martin-Uriz, Paula Aguirre-Ruiz, Pedro Vicente, Ricardo M Rosales, Ana María · 2026
Read A study on extracellular and cellular composition to advance towards the rational design of contractile human myocardium by Olalla Iglesias-García, Asier Ullate-Agote, Jiabin Qin, Aida Oliván-Viguera, Laura García-Mendívil, Gerardo Cedillo-Servin, Johannes Braig, Jose Valdés-Fernández, Inge Dokter, Ilazki Anaut-Lusar, Eduardo Larequi, Patxi San Martin-Uriz, Paula Aguirre-Ruiz, Pedro Vicente, Ricardo M Rosales, Ana María (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577836.txt.
Description
Engineered heart tissue grown in the lab could one day help repair damaged hearts, but recipes for building it vary. A research team compared two scaffold materials, fibrin and a gel called GelMA, and asked whether adding heart support cells called fibroblasts improves the tissue. Fibrin produced stronger results: the tissues formed better, contracted with more force, and organized their muscle fibers more evenly. The gel-based tissues were weaker on each of these measures.
Adding the support cells brought no gain. It made electrical behavior worse in the dish and raised the predicted risk of irregular rhythms in computer simulations. The findings suggest that simpler tissue recipes may work better than more complex ones.
Catalog record
| CREATOR | Olalla Iglesias-García, Asier Ullate-Agote, Jiabin Qin, Aida Oliván-Viguera, Laura García-Mendívil, Gerardo Cedillo-Servin, Johannes Braig, Jose Valdés-Fernández, Inge Dokter, Ilazki Anaut-Lusar, Eduardo Larequi, Patxi San Martin-Uriz, Paula Aguirre-Ruiz, Pedro Vicente, Ricardo M Rosales, Ana María |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |