Clobazam and Valproate, but Lamotrigine, a Sodium Channel Inhibitor, Reduce the Incidence of Hyperthermia‐Induced Clonic Seizures in Dravet Syndrome Mice: Assessment of Anti‐Seizure Effects in Mice Using a Stabilized Ambient Temperature System
Futa Sato, Mayuka Nakamura, Megumi Oishi, Yuki Matsuo, Naoki Amada, Takashi Wadatsu, Nobuyoshi Jinnai, Yusuke Kakumoto, Kenji Maeda, Yuki Yamasaki, Takashi Futamura · 2026
Read Clobazam and Valproate, but Lamotrigine, a Sodium Channel Inhibitor, Reduce the Incidence of Hyperthermia‐Induced Clonic Seizures in Dravet Syndrome Mice: Assessment of Anti‐Seizure Effects in Mice Using a Stabilized Ambient Temperature System by Futa Sato, Mayuka Nakamura, Megumi Oishi, Yuki Matsuo, Naoki Amada, Takashi Wadatsu, Nobuyoshi Jinnai, Yusuke Kakumoto, Kenji Maeda, Yuki Yamasaki, Takashi Futamura (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577812.txt.
Description
Futa Sato and colleagues test seizure drugs in Dravet syndrome mice under heat stress, in work from 2026. Dravet syndrome is a severe epilepsy that resists many drugs and often starts with fever fits. A gene fault in a sodium channel drives most cases in children with this condition.
Mutant mice sat in a warm chamber that raised body heat and sparked clonic seizures. Drugs were given by mouth half an hour before heat stress in each test round. Two drugs cut seizure counts clearly and delayed the first seizure in the mice. A sodium channel blocker drug gave no cut in seizure counts at all. Heat control was steady, so drug action drove the split.
Catalog record
| CREATOR | Futa Sato, Mayuka Nakamura, Megumi Oishi, Yuki Matsuo, Naoki Amada, Takashi Wadatsu, Nobuyoshi Jinnai, Yusuke Kakumoto, Kenji Maeda, Yuki Yamasaki, Takashi Futamura |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |