Functional and regulatory complexity: challenges and prospects for understanding rice WRKY transcription factors
Kamal Neupane, Federico Martin, Jan E Leach · 2026
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Description
Neupane and co-authors review why the WRKY family of transcription factors in rice is so hard to pin down, gene by gene. These proteins steer growth, development, and responses to pests, disease, drought, and other stresses. The family is large, its members overlap in structure and job, and each one plugs into wide regulatory networks.
That overlap is the core problem: knocking out one gene often changes little, because relatives cover for it or its role shifts with context. The review sorts methods by the barrier they address, grouping the barriers as context-dependent activity, multifunctionality, redundancy, and compensation. It also calls for shared WRKY-focused databases to speed up forming and testing ideas. A systems-level grasp of the family, the authors argue, is what breeding for tougher, higher-yielding rice will need.
Catalog record
| CREATOR | Kamal Neupane, Federico Martin, Jan E Leach |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |