Sublayer‐ and pathway‐specific control of CA1 input processing by VIP interneurons
Parisa Iloun, Jordan Grenier, Felix Veillette, Lisa Topolnik · 2026
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Description
Parisa Iloun and three co-authors study how a class of inhibitory brain cells shapes signals in the hippocampus, in a 2026 paper. These cells, marked by a peptide called VIP, can both block other cells directly and lift blocks by silencing blockers. How those twin actions sort signals across cell layers and input paths was unclear.
The team combined electrical recording with light and drug based control of the cells in the CA1 region. Direct blocking was similar for upper and lower layer target cells, though the contact types differed. Silencing the VIP cells changed each input path in its own way, favoring some layers and paths over others. The findings cast these cells as fine tuners of which signals get through.
Catalog record
| CREATOR | Parisa Iloun, Jordan Grenier, Felix Veillette, Lisa Topolnik |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |