Fission yeast RPA–TERT–Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination
Bettina A. Moser, Madeline Points, Sourav Agrawal, Adam C. Didier, Amanda K. Mennie, Ci Ji Lim, Yong-jie Xu, Toru M. Nakamura, Geraldine Butler, Soni Lacefield, Geraldine Butler, Soni Lacefield, Geraldine Butler, Soni Lacefield · 2026
Read Fission yeast RPA–TERT–Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination by Bettina A. Moser, Madeline Points, Sourav Agrawal, Adam C. Didier, Amanda K. Mennie, Ci Ji Lim, Yong-jie Xu, Toru M. Nakamura, Geraldine Butler, Soni Lacefield, Geraldine Butler, Soni Lacefield, Geraldine Butler, Soni Lacefield (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577582.txt.
Description
Bettina Moser and co-authors study how yeast cells keep the ends of their chromosomes long, in a 2026 paper. An enzyme lengthens those ends, called telomeres, but how it gets switched on after arrival was not clear. Work in human and other yeast cells hinted that a DNA guard protein helps. The team used gene screens, shape modeling, and targeted gene changes in fission yeast to test that idea.
They found a three part complex that helps lengthen the ends while also holding back a swap based repair path. Four contact points between the parts support the enzyme at work. Checks in other yeasts and humans suggest the setup is shared. Readers get a detailed model of how chromosome ends stay stable.
Catalog record
| CREATOR | Bettina A. Moser, Madeline Points, Sourav Agrawal, Adam C. Didier, Amanda K. Mennie, Ci Ji Lim, Yong-jie Xu, Toru M. Nakamura, Geraldine Butler, Soni Lacefield, Geraldine Butler, Soni Lacefield, Geraldine Butler, Soni Lacefield |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 118 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |