PRMT3 restricts porcine epidemic diarrhea virus replication by disrupting the interaction between VAPA and the viral nucleocapsid protein
He-Yong Wu, Shu-Yu Zhong, Ao-Si Qi, Zi-Ru Wang, Qiu-Se Tu, Feng Li, Rui Wu, Jing-Yao Wang, Fan Song, Tian-Yi Zhang, Ting Li, Qing-Chun Yu, Hong-Ming Yuan, Dong-Mei Lv, Hong-Sheng Ouyang, Xi-Liang Du, Da-Xin Pang, Zi-Cong Xie · 2026
Read PRMT3 restricts porcine epidemic diarrhea virus replication by disrupting the interaction between VAPA and the viral nucleocapsid protein by He-Yong Wu, Shu-Yu Zhong, Ao-Si Qi, Zi-Ru Wang, Qiu-Se Tu, Feng Li, Rui Wu, Jing-Yao Wang, Fan Song, Tian-Yi Zhang, Ting Li, Qing-Chun Yu, Hong-Ming Yuan, Dong-Mei Lv, Hong-Sheng Ouyang, Xi-Liang Du, Da-Xin Pang, Zi-Cong Xie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577570.txt.
Description
He-Yong Wu and co-authors present a 2026 study on a protein that blocks a pig diarrhea virus. The virus is a severe threat to swine herds worldwide. A genome-wide knockout screen singled out the protein, an enzyme that tags other proteins. Removing or blocking it sharply raised infection in several pig cell types.
The enzyme works by breaking a partnership between a host helper protein and the virus's shell protein. The helper normally ferries cholesterol and shields the shell protein from cell cleanup. Key contact points between the two were mapped to single amino acids. Blocking that handshake starved the virus. The authors name the pathway as a target for new antiviral drugs. It is the first report of this axis.
Catalog record
| CREATOR | He-Yong Wu, Shu-Yu Zhong, Ao-Si Qi, Zi-Ru Wang, Qiu-Se Tu, Feng Li, Rui Wu, Jing-Yao Wang, Fan Song, Tian-Yi Zhang, Ting Li, Qing-Chun Yu, Hong-Ming Yuan, Dong-Mei Lv, Hong-Sheng Ouyang, Xi-Liang Du, Da-Xin Pang, Zi-Cong Xie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |