Chloride-dependent mechanisms contribute to urinary bladder smooth muscle contractility: Pharmacological and molecular evidence from rat bladder tissue
Yuh-Chen Kuo, Vincent F. S. Tsai, Shih-Ping Liu, Jyh-Horng Chen, Hong-Chiang Chang, Ju-Ton Hsieh · 2026
Read Chloride-dependent mechanisms contribute to urinary bladder smooth muscle contractility: Pharmacological and molecular evidence from rat bladder tissue by Yuh-Chen Kuo, Vincent F. S. Tsai, Shih-Ping Liu, Jyh-Horng Chen, Hong-Chiang Chang, Ju-Ton Hsieh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13577559.txt.
Description
Kuo and colleagues report a 2026 study of how chloride ions help the bladder wall muscle contract, using rat tissue. Bladder squeezing is usually explained through calcium and potassium, with chloride less studied. The team checked bladder tissue for two chloride-related proteins, then mounted muscle strips in organ baths and varied the chloride around them.
Both proteins, ClC-3 and CLCA4, were present in the bladder lining and muscle layers. Replacing chloride with other ions, lowering its level, or applying chloride transport blockers changed how strongly the strips contracted under potassium or noradrenaline stimulation. The pattern shows chloride handling is a working part of bladder contraction, not a bystander. Naming the channels involved gives drug research new handles for overactive bladder, a common condition with limited treatment options.
Catalog record
| CREATOR | Yuh-Chen Kuo, Vincent F. S. Tsai, Shih-Ping Liu, Jyh-Horng Chen, Hong-Chiang Chang, Ju-Ton Hsieh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |