Convergent evolution of viral nucleases targeting cyclic dinucleotides
Zichen Li, Leiliang Zhang · 2026
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Description
Zichen Li and Leiliang Zhang trace a shared viral trick in a 2026 review. Cells use small ring molecules as alarm signals that switch on antiviral defenses. Poxviruses, a swine fever virus, and bacterial viruses each evolved enzymes that destroy those alarms.
The synthesis highlights three themes across the findings. Alarm signaling is conserved across life's domains, which is why so many viruses target it. The destroying enzymes took varied shapes to do the same job. Core protein folds persist and can swap function across species. The authors discuss drugs that block these enzymes or alarms built to resist them, toward broad antiviral therapy.
Catalog record
| CREATOR | Zichen Li, Leiliang Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |