Role of Rab4A in the enhancement of cancer cell invasion induced by plasma samples collected during radiotherapy in patients with triple-negative breast cancer
Benoit Paquette, Hélène Therriault, Isabelle Gauthier, Sawyna Provencher, Jean-Marc Bourque, Sahar Naasri, Ayman Oweida, Sameh Geha, Pascale Labrecque, Jean-Luc Parent · 2026
Read Role of Rab4A in the enhancement of cancer cell invasion induced by plasma samples collected during radiotherapy in patients with triple-negative breast cancer by Benoit Paquette, Hélène Therriault, Isabelle Gauthier, Sawyna Provencher, Jean-Marc Bourque, Sahar Naasri, Ayman Oweida, Sameh Geha, Pascale Labrecque, Jean-Luc Parent (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577393.txt.
Description
Benoit Paquette and a team of co-authors test a way to blunt a side effect of radiotherapy in an aggressive breast cancer. Their study appeared in twenty twenty-six. Triple-negative breast cancer returns more often than other types, and radiation can, in the lab, make cancer cells more invasive.
The team focuses on a protein called Rab4A, which controls recycling of a cutting enzyme on the cell surface. Lowering Rab4A in two cancer cell lines cut that enzyme's activity and the cells' power to invade. Blood taken during treatment from some patients made cancer cells invade more, and two of those patients later relapsed. Lowering Rab4A blocked the radiation-linked rise. The authors see the protein as a possible drug target.
Catalog record
| CREATOR | Benoit Paquette, Hélène Therriault, Isabelle Gauthier, Sawyna Provencher, Jean-Marc Bourque, Sahar Naasri, Ayman Oweida, Sameh Geha, Pascale Labrecque, Jean-Luc Parent |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |