Designer indicators for two-photon recording of subthreshold voltage dynamics

Michelle A Land, Mario Galdamez, Vincent Villette, Jun Zhu, Xiaoyu Lu, Mate Marosi, Shuyuan Yang, Gregory Foran, Alex J McDonald, Xiaoyu Dong, Elsayed Zaabout, Haixin Liu, Zhuohe Liu, Kevin L Colbert, Shujuan Lai, Matthew Shorey, Anthony S G Lourdiane, Annick Ayon, Jonathan Bradley, Caroline Mailhes · 2026

Read Designer indicators for two-photon recording of subthreshold voltage dynamics by Michelle A Land, Mario Galdamez, Vincent Villette, Jun Zhu, Xiaoyu Lu, Mate Marosi, Shuyuan Yang, Gregory Foran, Alex J McDonald, Xiaoyu Dong, Elsayed Zaabout, Haixin Liu, Zhuohe Liu, Kevin L Colbert, Shujuan Lai, Matthew Shorey, Anthony S G Lourdiane, Annick Ayon, Jonathan Bradley, Caroline Mailhes (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577304.txt.

Description

Subthreshold voltage dynamics are essential for neuronal information integration, yet they remain technically challenging to measure in vivo. While genetically encoded voltage indicators are emerging as powerful tools for voltage recording, they lack the sensitivity to detect millivolt-scale subthreshold fluctuations with two-photon microscopy—the method of choice for deep-tissue recording.

Catalog record

CREATORMichelle A Land, Mario Galdamez, Vincent Villette, Jun Zhu, Xiaoyu Lu, Mate Marosi, Shuyuan Yang, Gregory Foran, Alex J McDonald, Xiaoyu Dong, Elsayed Zaabout, Haixin Liu, Zhuohe Liu, Kevin L Colbert, Shujuan Lai, Matthew Shorey, Anthony S G Lourdiane, Annick Ayon, Jonathan Bradley, Caroline Mailhes
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE158 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13577304

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