Strain-resolved metabolomic chemotyping identifies tryptophan and γ-glutamyl peptides as MGO-AGEs breaking postbiotic compounds for carbonyl stress mitigation
Su-Hyun Kim, Seong-Min Hong, Eun Yoo Lee, Seul-Ah Kim, Nam Soo Han, Sun Yeou Kim, Choong Hwan Lee · 2026
Read Strain-resolved metabolomic chemotyping identifies tryptophan and γ-glutamyl peptides as MGO-AGEs breaking postbiotic compounds for carbonyl stress mitigation by Su-Hyun Kim, Seong-Min Hong, Eun Yoo Lee, Seul-Ah Kim, Nam Soo Han, Sun Yeou Kim, Choong Hwan Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577272.txt.
Description
Carbonyl stress builds up when reactive compounds like methylglyoxal pile up and damage tissue, a process tied to gut and mood disorders. Kim and co-authors built a strain-level screen to find bacterial extracts that can break down the harmful end products. They profiled 177 extracts from 113 strains and tested each one for breaking activity in the lab.
One extract stood out, rich in tryptophan and three small peptides. Given to mice under carbonyl stress, it restored gut length, tightened the gut lining, and lowered stress hormones and inflammation signals. The animals also showed fewer anxious and low-mood behaviors, and gut chemistry shifted toward protective compounds and away from toxic ones.
Catalog record
| CREATOR | Su-Hyun Kim, Seong-Min Hong, Eun Yoo Lee, Seul-Ah Kim, Nam Soo Han, Sun Yeou Kim, Choong Hwan Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |