Functional evidence of Hv1-mediated proton flux in cardiac mitochondria
Rayen De Fazio, Clara Ventura, Paulina Finochietto, Ernesto A Aiello, Carolina Jaquenod De Giusti, Verónica Milesi · 2026
Read Functional evidence of Hv1-mediated proton flux in cardiac mitochondria by Rayen De Fazio, Clara Ventura, Paulina Finochietto, Ernesto A Aiello, Carolina Jaquenod De Giusti, Verónica Milesi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577268.txt.
Description
Rayen De Fazio and five co-authors showed in 2026 that a proton channel known from other cells also works inside heart mitochondria. Mitochondria power the heartbeat, and their output hinges on how protons are moved and stored. The channel, called Hv1, lets protons out under voltage control and steadies cell acidity elsewhere in the body.
Working with mouse heart mitochondria, the team found the channel active there for the first time. Blocking it made the inner space more alkaline and raised the voltage across the membrane, both at work and at rest in whole heart cells. A new lever on heart energy is now in view.
Catalog record
| CREATOR | Rayen De Fazio, Clara Ventura, Paulina Finochietto, Ernesto A Aiello, Carolina Jaquenod De Giusti, Verónica Milesi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |