Protein sorting and proteostasis mechanisms in CFTR-related exocrine pancreas dysfunction: A systematic narrative review
Aime Patrick Niyomugabo, Leopold Ntakirutimana, Abdullateef Isiaka Alagbonsi · 2026
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Description
Aime Patrick Niyomugabo, Leopold Ntakirutimana, and Abdullateef Isiaka Alagbonsi review how faulty protein handling in the pancreas links to cystic fibrosis channel defects. The channel in question moves salts and alkali in the ducts that drain the digestive part of the pancreas. It must fold well and reach the cell surface to work.
Twenty studies met their rules, drawn from three databases across twenty-five years. Faulty channels fold badly, exit their birth compartment slowly, and recycle poorly, so fewer reach the surface. Neighboring transporters and juice proteins suffer too, hurting fluid flow and harming tissue. The authors back drugs that fix both the channel and its travel path.
Catalog record
| CREATOR | Aime Patrick Niyomugabo, Leopold Ntakirutimana, Abdullateef Isiaka Alagbonsi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |