Whole-genome sequencing guides the successful treatment of extensively drug-resistant TB
B. Makamure, J. Phelan, T. Bandason, M. Chipinduro, J. Mutsvangwa, J.Z. Metcalfe, F.T. Fernandez, J. Manasa · 2026
Read Whole-genome sequencing guides the successful treatment of extensively drug-resistant TB by B. Makamure, J. Phelan, T. Bandason, M. Chipinduro, J. Mutsvangwa, J.Z. Metcalfe, F.T. Fernandez, J. Manasa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577212.txt.
Description
Makamure and co-authors tell how full genome reading rescued care for a man with near untreatable tuberculosis. His strain resisted nearly all standard drugs. Lab growth tests gave clashing answers, and years of regimens failed amid stock gaps and tolerance trouble. In Zimbabwe, genome testing is still rare for cost and skill reasons.
Sequencing the germ's genome laid out its full resistance map at once. With that map, doctors could pick drugs the strain had not beaten. The letter walks through his long path from a wrong first regimen to the genome guided one. The authors argue that wider genome use would sharpen TB care and curb spread.
Catalog record
| CREATOR | B. Makamure, J. Phelan, T. Bandason, M. Chipinduro, J. Mutsvangwa, J.Z. Metcalfe, F.T. Fernandez, J. Manasa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |