“Gut-Joint Axis” Perspective on Immunometabolic Crosstalk in Osteoarthritis: A Narrative Review of Mechanistic Insights and Targeted Strategies
Yufeng Zhou, Hongzhen Du, Qian Zhang, Fantao Meng, Yimeng Wang, Jilin Fan, Wei Li · 2026
Read “Gut-Joint Axis” Perspective on Immunometabolic Crosstalk in Osteoarthritis: A Narrative Review of Mechanistic Insights and Targeted Strategies by Yufeng Zhou, Hongzhen Du, Qian Zhang, Fantao Meng, Yimeng Wang, Jilin Fan, Wei Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13577177.txt.
Description
Yufeng Zhou and six co-authors review the gut-joint axis in osteoarthritis, in a narrative review from 2026. Osteoarthritis is a whole-joint disease in which mechanical wear meets metabolic trouble and low-grade inflammation. Evidence increasingly ties gut microbe imbalance to joint damage, but the pathway has been scattered.
The review lays out a chain: a leaky gut barrier lets inflammatory signals into the blood, which reprograms immune and metabolic behavior in joint cells. That can deepen cartilage breakdown and bone change. The authors frame the gut as an amplifier, not the root cause. They discuss fixes aimed at gut microbes, the barrier, and the metabolic switch itself.
Catalog record
| CREATOR | Yufeng Zhou, Hongzhen Du, Qian Zhang, Fantao Meng, Yimeng Wang, Jilin Fan, Wei Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |