Prophase roles of replication protein A in crossover formation and meiotic progression
Rose M Lee, Keun Pil Kim, Jeong H Joo · 2026
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Description
Rose M Lee, Keun Pil Kim, and Jeong H Joo study a DNA-guarding protein during meiosis in yeast, in a 2026 paper. Meiosis is the cell division that makes sex cells, and it starts with deliberate DNA breaks that must be repaired into crossovers between partner chromosomes. Replication protein A coats the exposed single strands, yet its exact meiotic jobs were unclear.
The team switched the protein's large subunit off on demand using a degron tag. Without it, break processing faltered, chromosome axes assembled badly, and the zipper-like structure that pairs chromosomes formed poorly. Crossovers that depend on the ZMM protein family failed. Shutting down a checkpoint kinase that normally pauses the process did not rescue the damage. The authors cast the protein as a stabiliser that ties repair steps to pairing and crossover formation.
Catalog record
| CREATOR | Rose M Lee, Keun Pil Kim, Jeong H Joo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45617 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |