Twelve-month real-world outcomes of sparsentan in a multicenter Spanish IgA nephropathy cohort
Clara García-Carro, Antolina Rodríguez-Moreno, Lucía Cordero, María Vanessa Pérez-Gómez, Helena Marco Rusiñol, Enrique Pasache, Alejandro Morales, Rocío Zamora, Diego Parra, Juan Villa, Elena Guillén-Olmos, Verónica Coll-Brito, Álvaro Álvarez, Juliana Bordignon, Carola Arcal, Olga Gracia, Patricia D · 2026
Read Twelve-month real-world outcomes of sparsentan in a multicenter Spanish IgA nephropathy cohort by Clara García-Carro, Antolina Rodríguez-Moreno, Lucía Cordero, María Vanessa Pérez-Gómez, Helena Marco Rusiñol, Enrique Pasache, Alejandro Morales, Rocío Zamora, Diego Parra, Juan Villa, Elena Guillén-Olmos, Verónica Coll-Brito, Álvaro Álvarez, Juliana Bordignon, Carola Arcal, Olga Gracia, Patricia D (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13576413.txt.
Description
Clara García-Carro and co-authors follow a new kidney drug out of its trials and into Spanish hospital corridors, in this 2026 real-world study. Sparsentan cut protein leakage impressively in randomized trials of IgA nephropathy, the commonest glomerular disease. Whether the effect survives contact with ordinary practice, and ordinary patients, was unmeasured beyond the short term.
The multicenter review covers 41 biopsy-proven patients who started the drug outside any trial. Median age was forty-two; kidneys were already impaired, with median filtration at 44, and nearly all patients also took an SGLT2 inhibitor. Urine protein began at a median of 1,163 milligrams a day. Three months in, it had fallen to 772, a median drop of 44 percent, and just over half the patients passed the responder bar of halving their proteinuria. Six- and twelve-month data test whether the early win endures.
Catalog record
| CREATOR | Clara García-Carro, Antolina Rodríguez-Moreno, Lucía Cordero, María Vanessa Pérez-Gómez, Helena Marco Rusiñol, Enrique Pasache, Alejandro Morales, Rocío Zamora, Diego Parra, Juan Villa, Elena Guillén-Olmos, Verónica Coll-Brito, Álvaro Álvarez, Juliana Bordignon, Carola Arcal, Olga Gracia, Patricia D |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |