Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations
Changwei Wang, Prithwish Ghosh, Shicheng Jin, Longchuan Bai, Angelo Aguilar, Donna McEachern, Mi Wang, Qiuxia Li, Bo Wen, Duxin Sun, Shaomeng Wang · 2026
Read Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations by Changwei Wang, Prithwish Ghosh, Shicheng Jin, Longchuan Bai, Angelo Aguilar, Donna McEachern, Mi Wang, Qiuxia Li, Bo Wen, Duxin Sun, Shaomeng Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13576394.txt.
Description
Changwei Wang and co-authors build protein degraders against mutant KRAS in a 2026 study. Two KRAS changes, G12D and G12V, drive over half of cancers with a faulty KRAS gene. Instead of blocking the protein, degraders tag it for destruction by the cell. Their design uses a new gripper for the cell's disposal machinery.
The lead compound, CW-10201, cleared both mutant forms at very low doses in cells and halted growth of matching cancer lines at a few nanomoles. In mice it showed good drug levels and shrank one tumor model outright while slowing another, at doses the animals tolerated well. The team flags it for deeper study.
Catalog record
| CREATOR | Changwei Wang, Prithwish Ghosh, Shicheng Jin, Longchuan Bai, Angelo Aguilar, Donna McEachern, Mi Wang, Qiuxia Li, Bo Wen, Duxin Sun, Shaomeng Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |