Chlorogenic acid attenuates skin senescence and UVR-induced photoaging via the modulation of mitochondrial function
Rui Li, Chujuan Hu, Ping Zhou, Ge Si, Jinjin Cui, Yingying He, Yanxing Han, Jie Zhang, Wenbin Li, Lulu Wang, Jiandong Jiang · 2026
Read Chlorogenic acid attenuates skin senescence and UVR-induced photoaging via the modulation of mitochondrial function by Rui Li, Chujuan Hu, Ping Zhou, Ge Si, Jinjin Cui, Yingying He, Yanxing Han, Jie Zhang, Wenbin Li, Lulu Wang, Jiandong Jiang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13576369.txt.
Description
Rui Li leads a 2026 study of chlorogenic acid, a plant compound, as a defence against skin ageing and sun-driven photoageing. Mitochondria, the energy units of cells, sit at the centre of skin ageing, and the compound was known to affect them. The team tested it on human skin cells in the lab and on a mouse photoageing model.
In skin cells the compound raised collagen production through a known growth signal route, while lowering ageing markers and the inflammatory mix that old cells release. Energy output rose by roughly 40 to 80 percent, and damaged internal structures of mitochondria were repaired. Transplanting mitochondria confirmed the ageing benefit ran through them. In mice, a gel form given for 14 days protected collagen after ultraviolet exposure and calmed ageing signals. The authors propose the compound as a candidate anti-ageing agent.
Catalog record
| CREATOR | Rui Li, Chujuan Hu, Ping Zhou, Ge Si, Jinjin Cui, Yingying He, Yanxing Han, Jie Zhang, Wenbin Li, Lulu Wang, Jiandong Jiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66112 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |