Self-supplying hydrogen peroxide-driven gold nanoparticle aggregation via bio-orthogonal click reaction activates cGAS-STING-PERK pathway for multimodal tumor therapy
Junyou LI, Kaiqi Hu, Man Lung Lee, Ting Li, Pinyou Chen, Chengke Wang, Hung-Wing LI · 2026
Read Self-supplying hydrogen peroxide-driven gold nanoparticle aggregation via bio-orthogonal click reaction activates cGAS-STING-PERK pathway for multimodal tumor therapy by Junyou LI, Kaiqi Hu, Man Lung Lee, Ting Li, Pinyou Chen, Chengke Wang, Hung-Wing LI (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13576277.txt.
Description
Junyou Li leads a 2026 study of a nanoparticle platform that attacks tumours with four modes at once. Standard light-based therapy needs oxygen, which deep tumours lack. Their system pairs two plant-derived agents so the light reaction works without oxygen, producing superoxide radicals, while a manganese step makes further radicals and eases oxygen shortage.
One ingredient raises peroxide levels inside the tumour, powering a glow reaction that triggers gold particles to clump together for heat therapy deep in tissue without outside light. Stress on the cells' power units drains energy, frees mitochondrial DNA, and switches on an immune alarm pathway. The tumour setting shifted toward inflammation, with more attacker macrophages and fewer suppressor cells. Animal tests showed strong tumour clearance and blocked lung spread.
Catalog record
| CREATOR | Junyou LI, Kaiqi Hu, Man Lung Lee, Ting Li, Pinyou Chen, Chengke Wang, Hung-Wing LI |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67946 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |