Epigenetic safety of in vitro maturation in PCOS: genome-wide DNA methylation profiling of cord blood from a randomized controlled trial
Wei Guo, Yi Yang, Meng Qin, Siming Kong, Linlin Wang, Xiaoying Zheng, Rui Yang, Shuo Yang, Xiumei Zhen, Xiaohui Zhu, Rong Li, Liying Yan, Jie Qiao, Zhiqiang Yan · 2026
Read Epigenetic safety of in vitro maturation in PCOS: genome-wide DNA methylation profiling of cord blood from a randomized controlled trial by Wei Guo, Yi Yang, Meng Qin, Siming Kong, Linlin Wang, Xiaoying Zheng, Rui Yang, Shuo Yang, Xiumei Zhen, Xiaohui Zhu, Rong Li, Liying Yan, Jie Qiao, Zhiqiang Yan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13576222.txt.
Description
Wei Guo leads a 2026 study checking whether maturing eggs in the laboratory leaves marks on babies' DNA chemistry. The method, in vitro maturation, offers a gentler option than standard IVF for women with polycystic ovary syndrome, since it lowers the risk of dangerous ovary overstimulation. Worry persists that lab maturation might disturb early programming in offspring.
The analysis sat inside a randomised trial and covered ten families: five with lab-matured egg conception and five with standard IVF, parents included. Cord blood DNA from the babies showed closely matching methylation patterns between groups. Only three small differing regions appeared, none at imprinted or development-critical sites. Spread of values was also similar. The authors call the results strong support for the method's epigenetic safety.
Catalog record
| CREATOR | Wei Guo, Yi Yang, Meng Qin, Siming Kong, Linlin Wang, Xiaoying Zheng, Rui Yang, Shuo Yang, Xiumei Zhen, Xiaohui Zhu, Rong Li, Liying Yan, Jie Qiao, Zhiqiang Yan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54323 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |