Histone lactylation boosted SET8 potentiates carcinogenesis and angiogenesis of pancreatic ductal adenocarcinoma by cooperating with MTA1/NuRD complex
Xujun Liu, Abulaihaiti Tuergong, Mingzhen Wang, Weilong Shi, Xiaodong Tian, Xia Ting, Liyan Cui, Wenzhe Si · 2026
Read Histone lactylation boosted SET8 potentiates carcinogenesis and angiogenesis of pancreatic ductal adenocarcinoma by cooperating with MTA1/NuRD complex by Xujun Liu, Abulaihaiti Tuergong, Mingzhen Wang, Weilong Shi, Xiaodong Tian, Xia Ting, Liyan Cui, Wenzhe Si (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13576197.txt.
Description
Xujun Liu leads a 2026 study of a gene switch that fuels pancreatic cancer growth and blood vessel formation. The switch involves SET8, an enzyme that tags proteins, and its role in pancreatic ductal adenocarcinoma was unclear. A newer chemical tag, histone lactylation, driven by lactate in tumours, turned out to raise SET8 levels.
Tissue staining and database checks showed SET8 ran high in these tumours and marked worse outlooks. Lab assays found SET8 bound to a partner complex through the MTA1 protein. Together they silenced a tumour suppressor gene called SOCS2 by reshaping its chromatin. Removing SET8 or its partner cut tumour growth, vessel formation, and spread in the models used. Extra SET8 boosted cancer traits only when the partner was present. The authors propose blocking this axis as a treatment idea.
Catalog record
| CREATOR | Xujun Liu, Abulaihaiti Tuergong, Mingzhen Wang, Weilong Shi, Xiaodong Tian, Xia Ting, Liyan Cui, Wenzhe Si |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64966 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |