Tryptophan triggers the production of anthranilamide and quinazolinone derivatives in Streptomyces sp. PC4-3
Tam Pooprasert, Mark Aldren Feliciano, Sanya Sureram, Thammarat Aree, Nontaphat Leerach, Nopporn Chutiwitoonchai, Somboon Tanasupawat, Yongpeng Yao, Gang Liu, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop · 2026
Read Tryptophan triggers the production of anthranilamide and quinazolinone derivatives in Streptomyces sp. PC4-3 by Tam Pooprasert, Mark Aldren Feliciano, Sanya Sureram, Thammarat Aree, Nontaphat Leerach, Nopporn Chutiwitoonchai, Somboon Tanasupawat, Yongpeng Yao, Gang Liu, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13576157.txt.
Description
Tam Pooprasert and co-authors coax a soil bacterium into making new compounds by feeding it an amino acid, in a 2026 paper. Streptomyces bacteria are rich sources of useful chemicals, but many stay silent in the lab. Adding tryptophan to the culture of one strain boosted a family of compounds built around anthranilamide.
From the enriched culture the team isolated six compounds, three of them new to science. Two are mirror-arrangement variants of one molecule, and X-ray checks fixed which was which, a distinction never reported for them before. The trans form came out in far larger amounts than the cis. Two known compounds in the mix killed bacteria, though none touched the COVID virus in tests.
Catalog record
| CREATOR | Tam Pooprasert, Mark Aldren Feliciano, Sanya Sureram, Thammarat Aree, Nontaphat Leerach, Nopporn Chutiwitoonchai, Somboon Tanasupawat, Yongpeng Yao, Gang Liu, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |