Engineering controllable CAR T-cell therapies: from binary safety switches to programmable immunity
Sergei Smirnov, Yuriy Zaritskey, Galina Salogub, Alexander Fonin · 2026
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Description
Sergei Smirnov, Yuriy Zaritskey, Galina Salogub, and Alexander Fonin published a 2026 review on making CAR T-cell therapy controllable. In this cancer treatment, a patient's T cells are engineered with a chimeric antigen receptor that targets tumors. It has transformed blood cancer care, but standard receptors are always on.
That constant activity causes severe toxicities, including cytokine release syndrome, and wears the T cells out inside hostile tumors. Early fixes were kill switches that destroy the whole therapy when triggered. The review traces the field's move from such binary switches toward programmable designs, where doctors can tune, pause, or redirect the cells with drugs or logic circuits on the receptor itself.
Catalog record
| CREATOR | Sergei Smirnov, Yuriy Zaritskey, Galina Salogub, Alexander Fonin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |