Distributed clonal deletion prevents autoimmune disease progression
Anna M. Newen, Uzair A. Ansari, Mikala J. Simpson, Fiona Flynn, Sukriti Sharma, Michael Ivanov, Ishaan Antani, Dylan Pfannenstiel, Baktiar Karim, Laura Bassel, Brian Capaldo, Qingrong Chen, Daoud Meerzaman, Indu Raman, Chengsong Zhu, Cornelius Y. Taabazuing, Hamid Kashkar, Christian T. Mayer · 2026
Read Distributed clonal deletion prevents autoimmune disease progression by Anna M. Newen, Uzair A. Ansari, Mikala J. Simpson, Fiona Flynn, Sukriti Sharma, Michael Ivanov, Ishaan Antani, Dylan Pfannenstiel, Baktiar Karim, Laura Bassel, Brian Capaldo, Qingrong Chen, Daoud Meerzaman, Indu Raman, Chengsong Zhu, Cornelius Y. Taabazuing, Hamid Kashkar, Christian T. Mayer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13575929.txt.
Description
Anna M Newen leads a 2026 immunology study on how the body deletes self-reactive B cells before they cause autoimmune disease. B cells that target the body's own tissues arise during development. Some later sharpen their attack through a process driven by the AID enzyme, raising the risk of diseases such as lupus.
Using mice engineered so a cell-death step could be blocked at chosen stages, the team separated early from late checkpoints. Blocking the step early let self-reactive cells survive, diversify, and drive kidney damage with lethal disease. Blocking it after activation raised self-reactive cells and antibodies yet caused little tissue harm. The authors propose a model of deletion spread across stages, where early checkpoints carry the main protective weight.
Catalog record
| CREATOR | Anna M. Newen, Uzair A. Ansari, Mikala J. Simpson, Fiona Flynn, Sukriti Sharma, Michael Ivanov, Ishaan Antani, Dylan Pfannenstiel, Baktiar Karim, Laura Bassel, Brian Capaldo, Qingrong Chen, Daoud Meerzaman, Indu Raman, Chengsong Zhu, Cornelius Y. Taabazuing, Hamid Kashkar, Christian T. Mayer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37150 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |