Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care
Weerapong Lilitwat, Prakreeti Bhandari · 2026
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Description
Weerapong Lilitwat and Prakreeti Bhandari lay out a precision playbook for a runaway immune storm in sick children, in a 2026 review. The storm, hemophagocytic lymphohistiocytosis, floods young bodies with fever, shock, failing organs, and tangled blood counts, a mask much like severe sepsis. Old checklists name the disease but cannot say which gear drives it in one child. Their frame matches trigger and body pattern to pathway marks and drugs.
One signal mark backs a drug that blocks interferon gamma. Another pair backs a dampener used in macrophage storms. Wider signaling calls for a kinase blocker in stubborn cases, and a sixth interleukin drug fits a sibling storm from cell therapy. The authors stress these marks guide, not govern. Antibiotics, organ support, and early transplant planning run beside every targeted move, with a hard reassessment inside three days.
Catalog record
| CREATOR | Weerapong Lilitwat, Prakreeti Bhandari |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |