ZIF-8 Nanocarrier-Based Co-Delivery of Curcumin and 5-Fluorouracil for Synergistic Antitumor Activity in Hepatocellular Carcinoma
Long Zhang, Weijie Zhu, Lei He, Yuehan Zhang, Haibo Yang, Jinbao Xiao, Jiayi Zhao, Yunfei Huang, Jiannan Li · 2026
Read ZIF-8 Nanocarrier-Based Co-Delivery of Curcumin and 5-Fluorouracil for Synergistic Antitumor Activity in Hepatocellular Carcinoma by Long Zhang, Weijie Zhu, Lei He, Yuehan Zhang, Haibo Yang, Jinbao Xiao, Jiayi Zhao, Yunfei Huang, Jiannan Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575884.txt.
Description
Long Zhang and co-authors pack two liver cancer drugs into one acid-sensitive nanocarrier. Standard chemotherapy for this cancer suffers from weak targeting, resistance, and body-wide side effects. Their cage-like particle, ZIF-8, holds the classic drug 5-fluorouracil together with curcumin, a turmeric compound, and loosens its grip in the acidic air around tumors.
The loaded particles stayed stable and carried both drugs well. In dishes they killed far more liver cancer cells than either drug alone. In animals they shrank tumors by slowing cell growth, pushing cell death, and calming inflammation and oxidative stress, all while sparing healthy tissue. The authors pitch the pairing as a step toward precise, gentler therapy for a common and deadly cancer.
Catalog record
| CREATOR | Long Zhang, Weijie Zhu, Lei He, Yuehan Zhang, Haibo Yang, Jinbao Xiao, Jiayi Zhao, Yunfei Huang, Jiannan Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |