Sortase-mediated generation of various macrocyclic peptide scaffolds from low-reactivity electrophilic substrates
Zhe-Min Xia, Hui-Min Wei, Jun-Hao Xue, Ya-Ning Sun, Xiao-Cui Wan, Hua-Rong Tong, Li Zhou, Pan Shi, Ge-Min Fang, Changlin Tian · 2026
Read Sortase-mediated generation of various macrocyclic peptide scaffolds from low-reactivity electrophilic substrates by Zhe-Min Xia, Hui-Min Wei, Jun-Hao Xue, Ya-Ning Sun, Xiao-Cui Wan, Hua-Rong Tong, Li Zhou, Pan Shi, Ge-Min Fang, Changlin Tian (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575866.txt.
Description
Zhe-Min Xia and co-authors widen the shapes that ring peptides can take in a 2026 paper. Ring peptides resist gut enzymes, slip into tissue well, and hit targets with care, so drug hunters prize them. Libraries coded in genes let teams fish for new rings fast, but ring shapes hinge on the closing reaction used.
Their route uses the enzyme sortase to plant a mild reactive tag on display peptides, which then close onto a sulfur site in the same chain. Past no enzyme routes forced trades among speed, purity of target, and safety for the gene payload. The sortase path is gentle and yields varied ring frames from tame starting parts.
Catalog record
| CREATOR | Zhe-Min Xia, Hui-Min Wei, Jun-Hao Xue, Ya-Ning Sun, Xiao-Cui Wan, Hua-Rong Tong, Li Zhou, Pan Shi, Ge-Min Fang, Changlin Tian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |