Antibiotic-induced gut microbiota dysbiosis in the PICU: mechanisms, clinical outcomes, and management strategies – a narrative review
Cheng Yang, Dandan Wang, Wentao Peng · 2026
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Description
Cheng Yang, Dandan Wang, and Wentao Peng review how antibiotics disturb gut microbes in children's intensive care, in this 2026 paper. Nearly all children in these units receive antibiotics, and broad or combined courses are common. The drugs that kill oxygen-shunning gut bacteria do the deepest damage, the review finds.
Consequences include gut infections and lung infections tied to breathing machines. The authors put stewardship first: narrow the drug when possible and skip needless coverage. Probiotics helped in some studies but carry risk for fragile children. Fiber-rich feeding looks feasible, while newer options lack trials in this setting.
Catalog record
| CREATOR | Cheng Yang, Dandan Wang, Wentao Peng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |