Somatic Mitochondrial–Nuclear DNA Transfer in Lymphoproliferative Disorders
James Peter Stewart, Nikos Darzentas, Miguel Alcoceba, Maria Eugenia Sarasquete, Anthony V Moorman, Mark Catherwood, Binaya Regmi, Christiane Pott, Anton W Langerak, David Gonzalez · 2026
Read Somatic Mitochondrial–Nuclear DNA Transfer in Lymphoproliferative Disorders by James Peter Stewart, Nikos Darzentas, Miguel Alcoceba, Maria Eugenia Sarasquete, Anthony V Moorman, Mark Catherwood, Binaya Regmi, Christiane Pott, Anton W Langerak, David Gonzalez (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575760.txt.
Description
James Peter Stewart and co-authors published this 2026 study hunting for stray mitochondrial DNA lodged in the nuclear genome of blood cancers. Such transfers, known from solid tumors, had not been mapped in lymphoid malignancies. The team mined capture sequencing data from 755 cancers and 59 cell lines for the telltale junctions.
Five cancers, under one percent, carried a transfer. Most landed in the antibody heavy-chain genes, and one broke the PTEN tumor suppressor. The ragged breakpoints pointed to a quick patch-up repair route as the insertion mechanism. Rare as they are, the authors note, these fixed insertions could serve as stable fingerprints for tracking leftover disease after treatment.
Catalog record
| CREATOR | James Peter Stewart, Nikos Darzentas, Miguel Alcoceba, Maria Eugenia Sarasquete, Anthony V Moorman, Mark Catherwood, Binaya Regmi, Christiane Pott, Anton W Langerak, David Gonzalez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |