Human organoids and organ-on-chip systems for AI-guided therapeutic discovery against emerging and re-emerging infections
Sarbjeet Kaur Makkar, Simran Bhatia, Nhi Nguyen, Guoli Wei · 2026
Read Human organoids and organ-on-chip systems for AI-guided therapeutic discovery against emerging and re-emerging infections by Sarbjeet Kaur Makkar, Simran Bhatia, Nhi Nguyen, Guoli Wei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575619.txt.
Description
Sarbjeet Kaur Makkar, Simran Bhatia, Nhi Nguyen, and Guoli Wei review human mini-organs for drug hunting in a 2026 paper. New infections evolve faster than drug pipelines can move. Flat cell cultures scale well but miss the shape of real tissue. Animal models miss human-specific traits of infection and drug handling. Lab-grown organoids and organ-on-chip systems aim to close that gap.
Organoids supply organ-like human tissue, while chips add flow, barriers, and mechanical forces. The review covers their use against viruses, bacteria, parasites, and fungi. It weighs drug reuse, host-directed therapy, and safety testing in these systems. Smart software, rich imaging, and gene-level data can turn the models into loops that rank targets and drug pairs. Limits include cost and thin clinical proof so far.
Catalog record
| CREATOR | Sarbjeet Kaur Makkar, Simran Bhatia, Nhi Nguyen, Guoli Wei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |