Glyoxalase 1 loss reduces fatty liver but impairs glucose handling in male mice
Emely A Hoffman, Aiden M Phoebe, Marissa N Trujillo, Wei Chen Zhang, Erin Q Jennings, Dominique O Farrera, David J Orlicky, Lauren N Rutt, Rebecca L McCullough, Andrea A Huacachino, Mariola M Marcinkiewicz, Nathaniel W Snyder, Kassandra R Bruner, Kimberly Bassoco Payan, Diego Juan Federico Martinez, · 2026
Read Glyoxalase 1 loss reduces fatty liver but impairs glucose handling in male mice by Emely A Hoffman, Aiden M Phoebe, Marissa N Trujillo, Wei Chen Zhang, Erin Q Jennings, Dominique O Farrera, David J Orlicky, Lauren N Rutt, Rebecca L McCullough, Andrea A Huacachino, Mariola M Marcinkiewicz, Nathaniel W Snyder, Kassandra R Bruner, Kimberly Bassoco Payan, Diego Juan Federico Martinez, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575502.txt.
Description
Emely Hoffman and co-authors delete a detox enzyme in mice and watch the liver and blood sugar pull in opposite directions. Their 2026 study knocks out glyoxalase 1, which clears the sugar byproduct methylglyoxal. On a sixteen-week diet rich in fat and sugar, the knockout mice were expected to fare worse across the board.
Instead, their livers stored notably less fat than normal mice on the same diet. Body fat tissue showed no such change, and the kidneys looked unharmed. Yet blood sugar control clearly worsened, with higher fasting glucose and poorer tolerance in tests. The authors read the split as a lesson in tradeoffs: one enzyme can guard sugar handling while its absence relieves the liver. The work refines where glyoxalase-targeted drugs might help or harm.
Catalog record
| CREATOR | Emely A Hoffman, Aiden M Phoebe, Marissa N Trujillo, Wei Chen Zhang, Erin Q Jennings, Dominique O Farrera, David J Orlicky, Lauren N Rutt, Rebecca L McCullough, Andrea A Huacachino, Mariola M Marcinkiewicz, Nathaniel W Snyder, Kassandra R Bruner, Kimberly Bassoco Payan, Diego Juan Federico Martinez, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |