Chronic kidney disease and stromal cell-derived factor 1α peptide-functionalization impact on polycarbonate-bisurea based in situ tissue-engineered vascular graft dynamics
M. M. Krebber, P. J. Besseling, R. C. H. Driessen, A. M. Lichauco, W. Szymczyk, S. H. M. Söntjens, H. M. Janssen, M. Teraa, J. O. Fledderus, A. I. P. M. Smits, P. Y. W. Dankers, C. V. C. Bouten, M. C. Verhaar · 2026
Read Chronic kidney disease and stromal cell-derived factor 1α peptide-functionalization impact on polycarbonate-bisurea based in situ tissue-engineered vascular graft dynamics by M. M. Krebber, P. J. Besseling, R. C. H. Driessen, A. M. Lichauco, W. Szymczyk, S. H. M. Söntjens, H. M. Janssen, M. Teraa, J. O. Fledderus, A. I. P. M. Smits, P. Y. W. Dankers, C. V. C. Bouten, M. C. Verhaar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13575257.txt.
Description
M M Krebber leads a 2026 animal study of dissolvable blood vessel grafts and whether kidney disease changes how they heal. The grafts, spun from a polycarbonate-bisurea polymer, are meant to be replaced by the body's own tissue over time. A version coated with a cell-attracting peptide was also tested.
Grafts went into healthy rats and rats with induced kidney disease. After two weeks every graft stayed open and grew a lining with vessel and immune cells. Kidney disease animals worsened so fast that their arm of the study was stopped. In healthy rats followed for three months, some grafts widened, and four animals died after graft rupture linked to material breakdown. The peptide coating changed nothing measurable. The authors conclude the grafts grow tissue fast yet fail in ways not yet predictable.
Catalog record
| CREATOR | M. M. Krebber, P. J. Besseling, R. C. H. Driessen, A. M. Lichauco, W. Szymczyk, S. H. M. Söntjens, H. M. Janssen, M. Teraa, J. O. Fledderus, A. I. P. M. Smits, P. Y. W. Dankers, C. V. C. Bouten, M. C. Verhaar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48425 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |