The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis
Liang Guo, Baoying Huang, Hanzhi Yu, Yi Xu, Lei Wei, Jijie Zheng, Yuanzhe Li, Di Wu, Peng Zhao, Changcheng Wu, Wenjie Tan, Yichang Jia · 2026
Read The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis by Liang Guo, Baoying Huang, Hanzhi Yu, Yi Xu, Lei Wei, Jijie Zheng, Yuanzhe Li, Di Wu, Peng Zhao, Changcheng Wu, Wenjie Tan, Yichang Jia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575168.txt.
Description
Liang Guo and co-authors trace a viral sabotage of the cell's workshop in a 2026 virology paper. SARS-CoV-2's accessory protein ORF3a binds a chloride channel in the endoplasmic reticulum, skewing the compartment's ion balance, stressing its folding machinery, and reshaping internal membranes.
The channel fights back by trapping the viral protein in place, blunting its toxicity and slowing viral replication, which makes it a host restriction factor. Late in infection, the flood of viral protein escapes the trap and relocates to lysosomes, helping new virus leave. New reporter tools measured the tug of war. The same strategy appears across related coronaviruses.
Catalog record
| CREATOR | Liang Guo, Baoying Huang, Hanzhi Yu, Yi Xu, Lei Wei, Jijie Zheng, Yuanzhe Li, Di Wu, Peng Zhao, Changcheng Wu, Wenjie Tan, Yichang Jia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 117 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |