Cortico-pallidal beta dynamics underlie impaired turning in Parkinson’s disease
Poojan D. Shukla, Jessica E. Bath, Kenneth H. Louie, Hamid Fekri Azgomi, Rithvik Ramesh, Eleni Patelaki, Jacob H. Marks, Jannine P. Balakid, Doris D. Wang · 2026
Read Cortico-pallidal beta dynamics underlie impaired turning in Parkinson’s disease by Poojan D. Shukla, Jessica E. Bath, Kenneth H. Louie, Hamid Fekri Azgomi, Rithvik Ramesh, Eleni Patelaki, Jacob H. Marks, Jannine P. Balakid, Doris D. Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575165.txt.
Description
Poojan D. Shukla and colleagues taped brain signals during real walking and turning in five people with Parkinson's disease, using implants that both record and excite the brain. Turning is a daily yet tricky move that often fails in Parkinson's, causing falls and lost freedom, but its brain basis was unclear. Their 2026 study tracked motor cortex and deep-brain signals turn by turn.
Good turns showed falling beta-band signals and supple cortex-to-pallidum links, while failed turns showed too much beta sync that froze moves. Drugs and deep brain stimulation each helped, but in their own ways: dopamine calmed wayward pallidal beta, while pulses loosened the cortex. The authors point to these circuits as targets for smart pulses aimed at safer turning.
Catalog record
| CREATOR | Poojan D. Shukla, Jessica E. Bath, Kenneth H. Louie, Hamid Fekri Azgomi, Rithvik Ramesh, Eleni Patelaki, Jacob H. Marks, Jannine P. Balakid, Doris D. Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |