Transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis
Szabolcs Takács, Katalin Skrapits, Balázs Göcz, Éva Rumpler, Miklós Sárvári, Barbara Göblyös, Dalma Biri, Szilárd Póliska, Gergely Rácz, András Matolcsy, Erik Hrabovszky · 2026
Read Transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis by Szabolcs Takács, Katalin Skrapits, Balázs Göcz, Éva Rumpler, Miklós Sárvári, Barbara Göblyös, Dalma Biri, Szilárd Póliska, Gergely Rácz, András Matolcsy, Erik Hrabovszky (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575109.txt.
Description
Szabolcs Takács and co-authors profile gene activity in two human brain cell types that control appetite in a 2026 study. AgRP neurons drive hunger and energy storage, while POMC neurons curb feeding and spur energy use. Both sit in the hypothalamus, deep in the brain.
Their new method pairs staining with laser capture and gene sequencing in fixed human brain tissue. It read 14,000 to 16,000 gene transcripts in each cell type. The hunger cells were rich in receptors for inflammation signals and growth hormone. The satiety cells carried receptors for reproductive hormones and gut peptides. The maps point to drug targets for weight control.
Catalog record
| CREATOR | Szabolcs Takács, Katalin Skrapits, Balázs Göcz, Éva Rumpler, Miklós Sárvári, Barbara Göblyös, Dalma Biri, Szilárd Póliska, Gergely Rácz, András Matolcsy, Erik Hrabovszky |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |