Macrophage trained immunity requires a mitochondrial glutamine-restriction checkpoint for antitumor protection in mice
Ya Chun Yu, Yulseung Sung, Seonghun Lim, Jeong Ah Kwon, Min Ju Lee, Hyeong Yun Kim, Sunghoon Kim, Kuglae Kim, Do Sik Min, Hee Chan Yoo, Jung Min Han · 2026
Read Macrophage trained immunity requires a mitochondrial glutamine-restriction checkpoint for antitumor protection in mice by Ya Chun Yu, Yulseung Sung, Seonghun Lim, Jeong Ah Kwon, Min Ju Lee, Hyeong Yun Kim, Sunghoon Kim, Kuglae Kim, Do Sik Min, Hee Chan Yoo, Jung Min Han (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575105.txt.
Description
Ya Chun Yu and co-authors find a fuel gate that sets how well immune cells learn from a first threat. Their 2026 mouse study trains macrophages, the eating cells of the immune system, with a bacterial toxin. Training leaves the cells primed to fight harder later, even against tumors.
A deep scan of genes, fuels, and gene marks traced the training to one gate in the cell power plant. The gate limits intake of an amino fuel, which keeps a helpful gene mark in place and attack genes open. Blocking the gate sharpened training and tumor control, while forcing it open erased the gains. The chain offers drug targets for boosting innate defense.
Catalog record
| CREATOR | Ya Chun Yu, Yulseung Sung, Seonghun Lim, Jeong Ah Kwon, Min Ju Lee, Hyeong Yun Kim, Sunghoon Kim, Kuglae Kim, Do Sik Min, Hee Chan Yoo, Jung Min Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 103 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |