Polyamine metabolic enzyme SAT1 remodels the neuronal transcriptome and rescues α-synuclein toxicity in Drosophila
Zoya R. Bangash, Hiroyoshi Matsui, Bedri Ranxhi, Sokol V. Todi, Peter A. LeWitt, Wei-Ling Tsou · 2026
Read Polyamine metabolic enzyme SAT1 remodels the neuronal transcriptome and rescues α-synuclein toxicity in Drosophila by Zoya R. Bangash, Hiroyoshi Matsui, Bedri Ranxhi, Sokol V. Todi, Peter A. LeWitt, Wei-Ling Tsou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575090.txt.
Description
Zoya Bangash leads a team of six authors with a striking result. Boosting a polyamine-processing enzyme rescues fruit flies from alpha-synuclein. That protein is linked to Parkinson's disease. Polyamine balance plays a growing role in neurodegeneration. The enzyme SAT1 sits at the control center of that balance. The team used flies engineered to make alpha-synuclein in their neurons. Extra SAT1 lowered the levels of the protein. It redistributed the protein inside the brain. It also blunted the shortening of lifespan that the protein causes.
Gene expression profiling showed SAT1 quieting stress responses. Those responses include chaperone and protein-disposal genes. SAT1 also coordinated mitochondrial and amino acid pathways. Several mitochondrial quality-control genes that the toxic protein had disturbed were partly restored. A metabolic enzyme reshaping the neuronal transcriptome is the conceptual surprise of the paper.
Catalog record
| CREATOR | Zoya R. Bangash, Hiroyoshi Matsui, Bedri Ranxhi, Sokol V. Todi, Peter A. LeWitt, Wei-Ling Tsou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |