Evaluation of Drug–Drug Interactions Using Drug-PIN® in Patients Receiving Avelumab Maintenance for Advanced Urothelial Carcinoma: Evidence from the MALVA Study (Meet-URO 25)
Giandomenico Roviello, Mattia Alberto Di Civita, Daniele Santini, Elisabetta Gambale, Lidia Strigari, Simone Scagnoli, Laura Pappalardo, Andrea Torchia, Andrea Botticelli, Serena Pillozzi, Lorenzo Antonuzzo · 2026
Read Evaluation of Drug–Drug Interactions Using Drug-PIN® in Patients Receiving Avelumab Maintenance for Advanced Urothelial Carcinoma: Evidence from the MALVA Study (Meet-URO 25) by Giandomenico Roviello, Mattia Alberto Di Civita, Daniele Santini, Elisabetta Gambale, Lidia Strigari, Simone Scagnoli, Laura Pappalardo, Andrea Torchia, Andrea Botticelli, Serena Pillozzi, Lorenzo Antonuzzo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13575059.txt.
Description
Giandomenico Roviello leads a 2026 study of drug interactions in bladder cancer care, drawn from the MALVA study. Patients with advanced urothelial carcinoma often take many medicines at once, raising concern about harmful interactions. The group focused on people receiving avelumab, an immune therapy used as maintenance treatment.
Records for 115 patients were scored with Drug-PIN, a tool that rates interaction burden from a person's drug list and gene data. Scores varied widely between patients, yet adding avelumab did not shift them in a meaningful way. Survival and time without progression were similar across risk groups. The authors present the work as exploratory, noting that measured interaction burden showed no link to outcomes here.
Catalog record
| CREATOR | Giandomenico Roviello, Mattia Alberto Di Civita, Daniele Santini, Elisabetta Gambale, Lidia Strigari, Simone Scagnoli, Laura Pappalardo, Andrea Torchia, Andrea Botticelli, Serena Pillozzi, Lorenzo Antonuzzo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34397 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |