In silico analysis of MALAT1 and H19 lncRNA interactions with the diabetes-related proteins ASK1 and YAP1
Leonardo Elías Cabrera-Nájera, Olga Nelly Rodríguez-Peña, Cesar Mateo Flores-Ortíz, Martín Palomar-Morales · 2026
Read In silico analysis of MALAT1 and H19 lncRNA interactions with the diabetes-related proteins ASK1 and YAP1 by Leonardo Elías Cabrera-Nájera, Olga Nelly Rodríguez-Peña, Cesar Mateo Flores-Ortíz, Martín Palomar-Morales (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13575055.txt.
Description
Cabrera-Nájera and co-authors model how two long non-coding RNAs might grip diabetes-linked proteins, in a 2026 computer study. Long non-coding RNAs, or lncRNAs, do not build proteins but can steer cell signaling. The pair studied are MALAT1 and H19, and the proteins are ASK1 and YAP1, both tied to diabetes complications. A pipeline of structure prediction, docking, and molecular dynamics tested the pairings.
The proteins' shapes were predicted with high local confidence, while the RNAs stayed flexible, as expected. Docking placed MALAT1 on exposed faces of ASK1. H19 settled on YAP1 near spots known to control its activity, including switch sites used by partner proteins. Simulations showed loose, shifting contact rather than a rigid lock. The authors offer the maps as targets for lab tests.
Catalog record
| CREATOR | Leonardo Elías Cabrera-Nájera, Olga Nelly Rodríguez-Peña, Cesar Mateo Flores-Ortíz, Martín Palomar-Morales |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |