Complexity in disguise: a systematic review of fractal analysis in psychiatric neuroimaging

Marta Reales-Moreno, Alexandra Korda, Stefan Borgwardt · 2026

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Description

Marta Reales-Moreno's team reviewed fractal analysis as a way to characterise brain patterns in mental illness, in a 2026 systematic review. Mental-health diagnosis rests on symptoms and classifications, while brain scans hold complex organisation that standard tests may miss. Fractal dimension, a number capturing pattern complexity, promises a complementary lens. The team reviewed 39 original studies of brain-shape and brain-activity scans.

Schizophrenia and autism dominated the literature, and frontal-cortex abnormalities recurred across conditions. Whole-brain tests, however, may have diluted local effects by averaging too much tissue. The authors conclude fractal analysis reveals shared shape and activity patterns, but without a standard protocol its clinical use for earlier or sharper calls remains out of reach.

Catalog record

CREATORMarta Reales-Moreno, Alexandra Korda, Stefan Borgwardt
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE66 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13574870

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