In vivo labeling–based proteomic analysis of early follicle oocytes and cisplatin-induced alterations in mice
Zhi-Yan Jiang, Meiyu Bi, Xuan Wu, Miaomiao Ban, Yuyao Lu, Jiangli Cao, Jie Li, Qilong Wang, Xin Zhu, Mo Li, Heng-Yu Fan, Bingteng Xie · 2026
Read In vivo labeling–based proteomic analysis of early follicle oocytes and cisplatin-induced alterations in mice by Zhi-Yan Jiang, Meiyu Bi, Xuan Wu, Miaomiao Ban, Yuyao Lu, Jiangli Cao, Jie Li, Qilong Wang, Xin Zhu, Mo Li, Heng-Yu Fan, Bingteng Xie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13574812.txt.
Description
Zhi-Yan Jiang and co-authors profiled proteins in early egg cells of mice and tested a chemotherapy drug's effect in two thousand twenty-six. Protecting fertility during chemotherapy needs data on eggs in the earliest follicles, but such eggs are rare and hard to isolate. The team built mice whose egg proteins glow with a label.
With those mice they rebuilt the ovary in three dimensions and counted follicles precisely. They found two thousand seven hundred seventy-two proteins in eggs drawn mostly from primordial follicles. Short cisplatin treatment shifted proteins tied to DNA repair and histone change. Adding an inhibitor drug eased the defects cisplatin caused, a lead for fertility-saving care.
Catalog record
| CREATOR | Zhi-Yan Jiang, Meiyu Bi, Xuan Wu, Miaomiao Ban, Yuyao Lu, Jiangli Cao, Jie Li, Qilong Wang, Xin Zhu, Mo Li, Heng-Yu Fan, Bingteng Xie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |