Thrombin dynamics and clinical events in cirrhosis: low prothrombin conversion predicts bleeding risk
Ruth Anne Laura Willems, Alberto Zanetto, Elena Campello, Joke Konings, Cristiana Bulato, Matthijs Kramer, Francesco Paolo Russo, Mark Roest, Marco Senzolo, Patrizia Burra, Hugo ten Cate, Judith de Vos-Geelen, Bas de Laat, Paolo Simioni, Romy de Laat-Kremers · 2026
Read Thrombin dynamics and clinical events in cirrhosis: low prothrombin conversion predicts bleeding risk by Ruth Anne Laura Willems, Alberto Zanetto, Elena Campello, Joke Konings, Cristiana Bulato, Matthijs Kramer, Francesco Paolo Russo, Mark Roest, Marco Senzolo, Patrizia Burra, Hugo ten Cate, Judith de Vos-Geelen, Bas de Laat, Paolo Simioni, Romy de Laat-Kremers (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13574811.txt.
Description
Ruth Anne Laura Willems and co-authors track how thrombin behaves in patients with liver cirrhosis. Their 2026 study uses a computational add-on to the standard clotting test. Cirrhosis shifts both pro- and anti-clotting factors, leaving patients at risk of bleeding and clots at once, while the plain test often looks unchanged.
Ninety-five patients across three severity grades joined twenty healthy controls. Standard measures ran hotter in patients: peak thrombin was higher and arrived sooner. The deeper analysis splits the process into prothrombin conversion and thrombin shutoff, which the plain test blends together. Low conversion flagged the patients most likely to bleed. The authors argue this split view gives a sharper forecast of clinical events than the total curve alone.
Catalog record
| CREATOR | Ruth Anne Laura Willems, Alberto Zanetto, Elena Campello, Joke Konings, Cristiana Bulato, Matthijs Kramer, Francesco Paolo Russo, Mark Roest, Marco Senzolo, Patrizia Burra, Hugo ten Cate, Judith de Vos-Geelen, Bas de Laat, Paolo Simioni, Romy de Laat-Kremers |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |