Integrated proteomic and metabolomic analyses define the molecular architecture of acute mountain sickness
Wenjing Ding, Yifan Yang, Huaying Wei, Xinyu Hu, Haopeng Zhang, Ailifeila Aili, Xiaolan Chen, Qiqi Wang, Xinying Xue, Lei Pan · 2026
Read Integrated proteomic and metabolomic analyses define the molecular architecture of acute mountain sickness by Wenjing Ding, Yifan Yang, Huaying Wei, Xinyu Hu, Haopeng Zhang, Ailifeila Aili, Xiaolan Chen, Qiqi Wang, Xinying Xue, Lei Pan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13574784.txt.
Description
Wenjing Ding and nine co-authors map the molecular signature of acute mountain sickness with two layers of data at once. The sickness follows rapid exposure to high altitude, where low oxygen drives change in vessels, immunity, and metabolism. Blood plasma from 81 healthy Han Chinese men was profiled after fast ascent. The two layers together found 3,137 proteins and 4,104 small molecules.
Sick and healthy participants separated cleanly in the data. The sickness pattern joined activation of clotting and inflammation, disturbed blood clotting, and reshaped metabolism, with signals for energy production suppressed. Network analysis linked modules of proteins and molecules to headache severity, oxygen levels, and blood flow traits. Tissue mapping pointed to a pattern centered on the liver, spanning many organs.
Catalog record
| CREATOR | Wenjing Ding, Yifan Yang, Huaying Wei, Xinyu Hu, Haopeng Zhang, Ailifeila Aili, Xiaolan Chen, Qiqi Wang, Xinying Xue, Lei Pan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |