Real-World Outcomes Among Medicare Beneficiaries Treated with Bruton Tyrosine Kinase Inhibitors for Treatment-Naïve CLL
Daniel A Ermann, Deborah M Stephens, Xiaoliang Wang, Irene Varghese, Heidi De Souza, Caitlin Sheetz, Qianhong Fu, Gregory A Maglinte, Rhys Williams, Erlene K Seymour, Derrick van Beuge, Mazyar Shadman, Ryan Jacobs · 2026
Read Real-World Outcomes Among Medicare Beneficiaries Treated with Bruton Tyrosine Kinase Inhibitors for Treatment-Naïve CLL by Daniel A Ermann, Deborah M Stephens, Xiaoliang Wang, Irene Varghese, Heidi De Souza, Caitlin Sheetz, Qianhong Fu, Gregory A Maglinte, Rhys Williams, Erlene K Seymour, Derrick van Beuge, Mazyar Shadman, Ryan Jacobs (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13574742.txt.
Description
Daniel A Ermann, with 12 colleagues, reports a 2026 real-world study of a drug class for chronic lymphocytic leukaemia in older Americans. The drugs block Bruton tyrosine kinase, a signal the cancer needs, and several near twins compete with no head-to-head trial between them. Routine care data can fill that gap for patients who start treatment.
The team used a de-identified Medicare fee-for-service database, which covers most Americans over 65. Patients who began one of the rival drugs as first treatment were compared on outcomes that matter in practice, such as survival and staying on therapy. Trial patients skew younger and fitter than Medicare patients, so real-world gaps may emerge that trials miss. The comparison aims to guide first picks for a cancer of older age. The authors frame the data as a partner to trial results, not a swap.
Catalog record
| CREATOR | Daniel A Ermann, Deborah M Stephens, Xiaoliang Wang, Irene Varghese, Heidi De Souza, Caitlin Sheetz, Qianhong Fu, Gregory A Maglinte, Rhys Williams, Erlene K Seymour, Derrick van Beuge, Mazyar Shadman, Ryan Jacobs |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42233 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |